Children are a vulnerable population and constitute a major proportion of healthcare consumers in India, where nearly one-third of the population is below 15 years of age, making child health a national priority. School environments expose children to various risks such as accidents and injuries, and teachers, who supervise children for most of the school day, play a critical role in providing immediate first-aid care. This study aimed to evaluate the effectiveness of video-assisted teaching with demonstration on school teachers’ knowledge of selected first-aid measures and to examine the association between knowledge levels and selected socio-demographic variables. A single pre-test and post-test control group design was adopted, involving 60 school teachers from selected schools in Hassan, randomly assigned to experimental (N=30) and control (N=30) groups. Baseline data were collected using a structured questionnaire, after which the experimental group received video-assisted teaching with demonstration while the control group did not receive any intervention. The findings revealed that the experimental group showed a significant improvement in post-test knowledge scores compared to pre-test scores, with the mean score increasing from 22.87±3.58 to 38.30±2.15, while only minimal improvement was observed in the control group. A statistically significant difference was noted between the experimental and control groups at the 0.05 level, and knowledge scores were significantly associated with selected socio-demographic variables. The study concludes that video-assisted teaching with demonstration is an effective educational strategy for enhancing school teachers’ knowledge of selected first-aid measures and can be recommended as a practical approach to improve teachers’ preparedness in managing school-related emergencies and ensuring child safety.