Introduction: Menopause marks the natural cessation of menstruation and ovarian function, typically occurring between ages 45 and 55, due to decreased estrogen production. It involves significant changes affecting various bodily systems.

Methodology: This quasi-experimental study used a quantitative research approach to assess the impact of a nurse-led intervention on the quality of life, irritability, and coping abilities in managing post-menopausal problems among women in selected areas of the Ahmednagar district. An informal one-group pretest-posttest design was employed, involving 120 women over 40 years old who met specific inclusion and exclusion criteria, selected through non-probability convenience sampling. The inclusion criteria were women who were post-menopausal for at least 12 months, cognitively able to participate, willing to take part, and proficient in both English and Marathi. Exclusion criteria included women with menstrual disorders, those who had undergone hormone replacement therapy, and those with severe psychiatric disorders or chronic illnesses. The study's assessments included the Born–Steiner Irritability Scale: Self-Rating, and the Brief-Coping Orientation to Problems Experienced Inventory (Brief-COPE).

Result: Results showed substantial improvements post-intervention: Irritability levels of post-menopausal women significantly decreased, with severe irritability dropping from 69.17% to 5.83%, and the mean irritability score decreasing from 30.93 to 14.76. Coping abilities improved, with the percentage of women demonstrating good coping skills rising from 9% to 30.83%, and the mean coping ability score increasing from 52.96 to 73.54.

Conclusion: These results highlight the intervention's effectiveness in reducing irritability, and improving coping skills among post-menopausal women, emphasizing the potential benefits of targeted nurse-led programs.