Objective: Aim of this systematic review is to systematically evaluate the knowledge and attitude towards ill effects of tobacco and alcohol among adolescents.

Methods: It includes systematic review of literature from 2010 to 2020. Studies were sourced from a total of 5 databases: PubMed, Cochrane, Google scholar, World health organization and Global Adult tobacco survey: GATS ATLAS. All possible studies were identified for review through search terms and search strategy. Inclusion criteria were primary research study that was published in English and conducted among adolescents.

Findings: Nineteen studies met the inclusion criteria in relation to aspect of knowledge and attitude towards ill effects of tobacco and alcohol. The review highlighted that the adolescent were indulge in the act of substance abuse. Knowledge among adolescent were found to be adequate. Even though the knowledge was present, the prevalence of tobacco and substance abuse was found to be higher. Few studies revels that there were negative attitude towards substance abuse.

Conclusion: This systematic review provides an overview of the knowledge and attitude towards ill effects of tobacco and alcohol. The review also highlighted the need for provision of educational and awareness programme for adolescents.