A descriptive survey study was conducted (2022) on assessment of knowledge and practices regarding prevention of COVID- 19 among adults residing in selected urban community, Paschim Medinipur, West Bengal with the objectives to assess the knowledge, to identify the practices, to find out the co-relation between knowledge and practices, to determine the association between knowledge and practices with selected demographic variables. 110 participants were selected by systematic random sampling technique. Semi structured and structured interview schedule, structured three point rating scale tools were used for collect data. The study findings revealed that 49.09% and 47.27% respondents had good knowledge and good practice score respectively regarding prevention of COVID-19. There were strong positive correlation (r = 0.718) between knowledge and practices at 0.01 level of significance. There were significant association between knowledge with educational status, monthly income of family and history of suffering from COVID-19 of family members and practices with type of family, educational status of respondents at 0.05 level. All respondents get information regarding COVID-19 and vaccinated. The study can be replicated in large population.