Introduction: A severe multisystem inflammatory syndrome associated with Kawasaki disease manifestations (MIS-C) has been reported in children with signs of recent infection with SARS-CoV-2. We here reported the case of a young adult woman who presented the complete manifestations of Kawasaki disease associated with a severe myocarditis, acute respiratory distress syndrome and hemodynamic instability a few weeks after a transient anosmia.

Methodology: A quantitative approach with one group pre-test design was used for the study. The samples consisted of 60 staff nurses selected by Non probability purposive sampling technique. Research design was pre-experimental one group pre-test and post-test design. Main study was conducted from 01/05/2022 to 15/06/2022 Data was collected by administering a structured knowledge questionnaire by the investigator before and after self-instructional module. Post-test was conducted after 7 days of pre-test and intervention. Data was analyzed using descriptive & inferential statistics (Paired ‘t’ test, Chi- square test, Karl- Person’s correlation coefficient.

Result: The pretest knowledge score was 9.05±2.45, while the posttest knowledge score was 19.98±2.57. The difference was found to be statistically significant (‘t’ value = -24.62, df=59, p value=0.05, Significant), showing a higher posttest knowledge score.

Conclusion: The finding in the study proved that the structured teaching programme is effective in improving knowledge of staff nurses. The entire subject had improved in knowledge compared to their pre- test score.