Introduction: Our hands do so much for us. They are capable of a wide variety of functions like touching, grasping, feeling, holding, manipulating, caressing, and performing daily activities and more. They are a vitally important part of who we are and how we see ourselves.” Good hand hygiene is one of the most critical control strategies in outbreak management. Hand hygiene is defined as any method that removes or destroys microorganisms on hands.

Objective: The main aim of the study is to assess the effectiveness of planned teaching module on knowledge regarding hand hygiene status among secondary school at selected urban area of kokapet, Ranga Ready District Andhra Pradesh.

Research methodology: A pre experimental one group pre-test and post-test design study conducted on 60 students of secondary school. The sample selected through convenient sampling technique. The dependent variable includes knowledge of students and independent variables include planned teaching module regarding hand hygiene. The data collected through structured knowledge questionnaire.

Results: The mean knowledge score of the participants regarding hand hygiene was 13.55±2.41 before administration of the planned teaching module whereas 18.13±2.19 after administration of planned teaching programme. The value of t was 11.01. It was found to be statistically significant at p <0.001.

Conclusion: The study finding proved that the planned teaching module administered by the researcher was effective to increase the knowledge of the secondary school children on hand hygiene